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CS-W001157 4
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3-(Difluoromethyl)pyridin-2-amine

  • CAS No. 878804-93-4

  • Cat. No. CS-0161222
  • Purity≥97%
  • MDL No.MFCD19213737

*For research and further manufacturing use only, not for direct human use.

3-(Difluoromethyl)pyridin-2-amine|CS-0161222

Structure of 878804-93-4

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General Information

  • CAS No. 878804-93-4
  • Cat. No. CS-0161222
  • Purity ≥97%
  • MDL No. MFCD19213737
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆F₂N₂
  • Molecular Weight 144.12
  • Synonym(s) 2-Amino-3-(difluoromethyl)pyridine
  • SMILES NC1=NC=CC=C1C(F)F

Description

3-(Difluoromethyl)pyridin-2-amine integrates a difluoromethyl group at the 3-position of a pyridin-2-amine scaffold, delivering enhanced metabolic stability and improved membrane permeability. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct incorporation into kinase inhibitors and other bioactive scaffolds through facile functionalization at the amine and pyridine sites.

Application

3-(Difluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group into bioactive scaffolds. Its pyridine nitrogen and primary amine functionality offer orthogonal reactivity for derivatization via coupling, alkylation, or cyclization reactions. The molecule exhibits good bench stability and facilitates efficient functionalization under standard synthetic conditions, making it well-suited for rapid analog generation in drug discovery programs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.6014
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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