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CS-W001157 4
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4-Chloro-2,3-difluoroaniline

  • CAS No. 878285-12-2

  • Cat. No. CS-W022137
  • Purity≥98%
  • MDL No.MFCD08459284

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2,3-difluoroaniline|CS-W022137

Structure of 878285-12-2

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General Information

  • CAS No. 878285-12-2
  • Cat. No. CS-W022137
  • Purity ≥98%
  • MDL No. MFCD08459284
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₂N
  • Molecular Weight 163.55
  • Synonym(s) 4-chloro-2,3-difluoro-aniline
  • SMILES NC1=CC=C(Cl)C(F)=C1F

Description

4-Chloro-2,3-difluoroaniline is a fluorinated aromatic amine featuring chlorine and two fluorine substituents in a strategic ortho/meta arrangement. This electron-deficient aniline derivative enables direct incorporation into pharmaceutical intermediates and agrochemical scaffolds, offering enhanced metabolic stability and tunable reactivity under standard coupling conditions.

Application

4-Chloro-2,3-difluoroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling the construction of fluorinated heterocycles and bioactive scaffolds. Its ortho-difluoro substitution pattern enhances metabolic stability and modulates electronic properties, while the aniline functionality facilitates direct coupling reactions and electrophilic substitutions. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthetic workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.2004
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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