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CS-W001157 4
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Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride

  • CAS No. 877861-62-6

  • Cat. No. CS-0039075
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride|CS-0039075

Structure of 877861-62-6

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General Information

  • CAS No. 877861-62-6
  • Cat. No. CS-0039075
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄ClNO₂
  • Molecular Weight 227.69
  • Synonym(s) methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate, HCl salt
  • SMILES COC(=O)C1=CC=C2CNCCC2=C1.Cl

Description

Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride offers a stable, moisture-tolerant platform for synthesizing bioactive isoquinoline derivatives. The protonated nitrogen enhances solubility in polar media, while the ester functionality enables direct derivatization. This salt form simplifies handling and storage under standard bench conditions, facilitating integration into multi-step synthetic sequences.

Application

Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride serves as a versatile building block for medicinal chemistry and natural product synthesis. The tetrahydroisoquinoline core provides a rigid, bioactive scaffold, while the methyl ester enables further functionalization via hydrolysis or coupling reactions. The hydrochloride salt enhances solubility and stability in aqueous and polar organic media, facilitating handling and purification. This compound functions effectively in standard transition-metal-catalyzed cross-couplings and reductive aminations, enabling efficient access to complex alkaloid frameworks and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.5407
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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