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CS-W001157 4
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2-Iodooxazole

  • CAS No. 877614-97-6

  • Cat. No. CS-0051894
  • Molecule weight194.96
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Iodooxazole|CS-0051894

Structure of 877614-97-6

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General Information

  • CAS No. 877614-97-6
  • Cat. No. CS-0051894
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₂INO
  • Molecular Weight 194.96
  • Synonym(s) 2-Iodo-1,3-oxazole
  • SMILES IC1=NC=CO1

Description

2-Iodooxazole is a bench-stable heterocyclic iodide featuring a reactive iodine atom at the 2-position, enabling direct functionalization in transition-metal-catalyzed cross-coupling reactions. The oxazole ring provides electronic stability and enhances solubility in common organic solvents. This compound serves as a key building block for synthesizing complex nitrogen-containing architectures in medicinal chemistry and materials science.

Application

2-Iodooxazole serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the oxazole ring via palladium-catalyzed cross-coupling reactions. Its iodine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, facilitating the construction of complex heterocyclic scaffolds. The compound exhibits excellent bench stability and compatibility with common protecting groups, making it well-suited for iterative synthesis workflows in medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.03
  • LogP   1.2792
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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