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CS-W001157 4
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Benzyl (S)-3-aminopiperidine-1-carboxylate

  • CAS No. 876461-55-1

  • Cat. No. CS-W021176
  • Purity≥97%
  • MDL No.MFCD08061980

*For research and further manufacturing use only, not for direct human use.

Benzyl (S)-3-aminopiperidine-1-carboxylate|CS-W021176

Structure of 876461-55-1

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General Information

  • CAS No. 876461-55-1
  • Cat. No. CS-W021176
  • Purity ≥97%
  • MDL No. MFCD08061980
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈N₂O₂
  • Molecular Weight 234.29
  • Synonym(s) 1-Piperidinecarboxylicacid, 3-amino-, phenylmethyl ester, (3S)-
  • SMILES O=C(N1C[C@@H](N)CCC1)OCC2=CC=CC=C2

Description

Benzyl (S)-3-aminopiperidine-1-carboxylate features a chiral (S)-3-aminopiperidine core with a benzyl ester handle, enabling selective functionalization in asymmetric synthesis. This bench-stable derivative delivers enhanced solubility and compatibility in peptide coupling and medicinal chemistry workflows.

Application

Benzyl (S)-3-aminopiperidine-1-carboxylate serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. Its benzyl ester group offers enhanced bench stability and simplifies purification, while the secondary amine supports diverse functionalization via standard coupling and reductive amination protocols. This compound functions as a key intermediate in the synthesis of bioactive molecules, particularly those requiring stereocontrolled piperidine motifs.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1690 - 1694
  • Route2
    • tert-Butyl (S)-piperidin-3-ylcarbamate Linagliptin impurity|CS-1311968
      216854-23-8
    • ~%
    • In-stock
      Benzyl (S)-3-aminopiperidine-1-carboxylate|CS-W021176
      876461-55-1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1690 - 1694
  • Route3
    • null|null
      501-53-1
    • ~%
    • In-stock
      Benzyl (S)-3-aminopiperidine-1-carboxylate|CS-W021176
      876461-55-1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1690 - 1694

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   1.7463
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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