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CS-W001157 4
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3-Bromopyrazolo[1,5-a]pyridine-5-carboxylic acid

  • CAS No. 876379-79-2

  • Cat. No. CS-0155566
  • Purity≥95%
  • MDL No.MFCD11518932

*For research and further manufacturing use only, not for direct human use.

3-Bromopyrazolo[1,5-a]pyridine-5-carboxylic acid|CS-0155566

Structure of 876379-79-2

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General Information

  • CAS No. 876379-79-2
  • Cat. No. CS-0155566
  • Purity ≥95%
  • MDL No. MFCD11518932
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂O₂
  • Molecular Weight 241.04
  • Synonym(s) None
  • SMILES C1=CN2C(=C(C=N2)Br)C=C1C(=O)O

Description

3-Bromopyrazolo[1,5-a]pyridine-5-carboxylic acid features a brominated pyrazolopyridine core paired with a carboxylic acid group, enabling direct conjugation or derivatization. The electron-deficient heterocycle supports transition metal-catalyzed coupling reactions, while the carboxylic acid facilitates salt formation and solubility tuning for synthetic applications in medicinal chemistry and materials science.

Application

3-Bromopyrazolo[1,5-a]pyridine-5-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling direct functionalization at the pyrazolo[1,5-a]pyridine core. Its bromo and carboxylic acid groups facilitate palladium-catalyzed cross-coupling and amide formation, respectively, with excellent bench stability and straightforward purification. This compound functions as a key intermediate in the construction of bioactive scaffolds relevant to medicinal chemistry and agrochemical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.6
  • LogP   1.795
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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