2,4-Dichloro-5-fluoroquinazoline

Name: 2,4-Dichloro-5-fluoroquinazoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 87611-00-5
Cat. No. CS-0045342
Purity≥95%
MDL No.MFCD09954883

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2,4-Dichloro-5-fluoroquinazoline|CS-0045342

Structure of 87611-00-5

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Description

2,4-Dichloro-5-fluoroquinazoline serves as a pivotal building block in medicinal chemistry, featuring a halogenated quinazoline core that enables direct functionalization via cross-coupling. The electron-deficient framework supports efficient palladium-catalyzed reactions, while the orthogonal reactivity of chlorine and fluorine atoms allows for sequential derivatization. This compound exhibits excellent stability under standard bench conditions and integrates readily into kinase inhibitor scaffolds.

Application

2,4-Dichloro-5-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinazoline-based scaffolds. Its ortho-dichloro substitution pattern facilitates regioselective nucleophilic aromatic substitution, while the 5-fluoro group enhances reactivity toward amines and thiols. The compound exhibits good bench stability and is readily purified by column chromatography, making it ideal for use in iterative synthesis campaigns targeting kinase inhibitors and other bioactive heterocycles.

General Information

CAS No. 87611-00-5
Cat. No. CS-0045342
Purity ≥95%
MDL No. MFCD09954883
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₃Cl₂FN₂
Molecular Weight 217.03
Synonym(s) 4-dichloro-5-fluoroquinazoline
SMILES FC1=CC=CC2=C1C(Cl)=NC(Cl)=N2

Computational Chemistry Data

TPSA 25.78
LogP 3.0757
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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2,4-Dichloro-5-fluoroquinazoline

CAS No. 87611-00-5

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