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CS-W001157 4
Total: USD 88.00

4-Chlorophenyl acetate

  • CAS No. 876-27-7

  • Cat. No. CS-0197466
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chlorophenyl acetate|CS-0197466

Structure of 876-27-7

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General Information

  • CAS No. 876-27-7
  • Cat. No. CS-0197466
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇ClO₂
  • Molecular Weight 170.59
  • Synonym(s) PARA-CHLOROPHENYLACETATE
  • SMILES CC(=O)OC1=CC=C(C=C1)Cl

Description

4-Chlorophenyl acetate is a bench-stable phenolic ester featuring a chlorine-substituted aromatic ring that enhances electronic withdrawal and metabolic stability. This compound serves as a selective acetyl transfer agent in synthetic transformations, particularly useful in protecting group strategies and peptide derivatization workflows where controlled release of acetyl groups is required.

Application

4-Chlorophenyl acetate serves as a stable, bench-ready aryl acetyl protecting group for phenolic hydroxyls. It facilitates selective acetylation in multi-functional systems and enables orthogonal deprotection under mild conditions. The compound exhibits excellent functional group tolerance and is compatible with standard synthetic workflows, including cross-coupling and nucleophilic substitution reactions. Its predictable reactivity makes it a reliable choice for intermediate synthesis in pharmaceutical and agrochemical development.

Synthesis

  • Route1
    • null|null
      106-48-9
    • null|null
      75-36-5
    • ~96%
    • In-stock
      4-Chlorophenyl acetate|CS-0197466
      876-27-7

    References

    • Sharghi, Hashem; Jokar, Mahboubeh; Doroodmand, Mohammad Mahdi Advanced Synthesis and Catalysis, 2011 , vol. 353, # 2-3 p. 426 - 442
  • Route2
    • null|null
      108-24-7
    • null|null
      106-48-9
    • ~99%
    • In-stock
      4-Chlorophenyl acetate|CS-0197466
      876-27-7

    References

    • Chakraborti, Asit K.; Sharma, Lalima; Gulhane, Rajesh; Shivani Tetrahedron, 2003 , vol. 59, # 39 p. 7661 - 7668
  • Route3
    • tert-Butyl(4-chlorophenoxy)dimethylsilane|CS-0776243
      126644-72-2
    • null|null
      108-24-7
    • ~84%
    • In-stock
      4-Chlorophenyl acetate|CS-0197466
      876-27-7

    References

    • Du, Ti-Jian; Wu, Qin-Pei; Liu, Hai-Xia; Chen, Xi; Shu, Yi-Nan; Xi, Xiao-Dong; Zhang, Qing-Shan; Li, Yun-Zheng Tetrahedron, 2011 , vol. 67, # 6 p. 1096 - 1101

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.2653
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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