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CS-W001157 4
Total: USD 88.00

Cinnolin-4-ol

  • CAS No. 875-66-1

  • Cat. No. CS-0088124
  • Purity≥95%
  • MDL No.MFCD00956158

*For research and further manufacturing use only, not for direct human use.

Cinnolin-4-ol|CS-0088124

Structure of 875-66-1

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General Information

  • CAS No. 875-66-1
  • Cat. No. CS-0088124
  • Purity ≥95%
  • MDL No. MFCD00956158
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O
  • Molecular Weight 146.15
  • Synonym(s) 4-HYDROXY-CINNOLINE
  • SMILES OC1=C2C=CC=CC2=NN=C1

Description

Cinnolin-4-ol serves as a key heterocyclic scaffold for synthesizing bioactive molecules, featuring a hydroxyl group at the 4-position that enhances reactivity in cross-coupling and cyclization reactions. This bench-stable compound integrates readily into pharmaceutical intermediates and functional materials, offering high versatility in medicinal chemistry applications.

Application

Cinnolin-4-ol serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the 4-position through palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient access to substituted cinnoline scaffolds relevant to medicinal chemistry and materials science.

Synthesis

  • Route1

    References

    • Gautheron Chapoulaud; Ple; Turck; Queguiner Tetrahedron, 2000 , vol. 56, # 30 p. 5499 - 5507
  • Route2
    • null|null
      1066-54-2
    • ~%
    • In-stock
      Cinnolin-4-ol|CS-0088124
      875-66-1

    References

    • Tetrahedron Letters, , vol. 40, # 34 p. 6201 - 6203
  • Route3

    References

    • Tetrahedron, , vol. 56, # 30 p. 5499 - 5507

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   1.3354
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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