(R)-methyl pyrrolidine-3-carboxylate hydrochloride

Name: (R)-methyl pyrrolidine-3-carboxylate hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 874964-22-4
Cat. No. CS-B0685
Molecule weight165.62
Purity≥97%
MDL No.MFCD11840195

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(R)-methyl pyrrolidine-3-carboxylate hydrochloride|CS-B0685

Structure of 874964-22-4

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General Information

CAS No. 874964-22-4
Cat. No. CS-B0685
Purity ≥97%
MDL No. MFCD11840195
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₂ClNO₂
Molecular Weight 165.62
Synonym(s) R-3-Pyrrolidinecarboxylic acid Methyl ester hydrochloride
SMILES O=C([C@H]1CNCC1)OC.Cl

Description

(R)-methyl pyrrolidine-3-carboxylate hydrochloride is a bench-stable, moisture-tolerant chiral building block featuring a defined (R)-configuration at the C3 position. This configuration imparts predictable stereochemical control in asymmetric synthesis. The hydrochloride salt enhances solubility and handling, enabling efficient incorporation into peptide mimetics, pharmaceutical intermediates, and catalytic systems requiring high enantiomeric purity.

Application

(R)-Methyl pyrrolidine-3-carboxylate hydrochloride serves as a chiral building block for synthesizing bioactive molecules and pharmaceutical intermediates. Its stable, crystalline form facilitates handling and purification, while the protected amine and ester functionalities enable selective transformations in multistep syntheses. Functions effectively in asymmetric synthesis, enabling access to pyrrolidine-based scaffolds common in medicinal chemistry.

Synthesis

Route1
- 67-56-1
- In-stock
  
  72925-16-7
- ~98%
- In-stock
  
  874964-22-4
References
- SMITHKLINE BEECHAM CORPORATION Patent: WO2009/5998 A1, 2009 ; Location in patent: Page/Page column 244 ;
Route2
- In-stock
  
  441717-40-4
- ~%
- In-stock
  
  874964-22-4
References
- WO2007/70398 A1, ; Page/Page column 188 ; WO 2007/070398 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.33
LogP 0.1907
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-methyl pyrrolidine-3-carboxylate hydrochloride

CAS No. 874964-22-4

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