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CS-W001157 4
Total: USD 88.00

1-(2-Bromophenyl)pyrazole

  • CAS No. 87488-84-4

  • Cat. No. CS-0060463
  • Molecule weight223.07
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(2-Bromophenyl)pyrazole|CS-0060463

Structure of 87488-84-4

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General Information

  • CAS No. 87488-84-4
  • Cat. No. CS-0060463
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇BrN₂
  • Molecular Weight 223.07
  • Synonym(s) 1H-pyrazole, 1-(2-bromophenyl)-
  • SMILES C1=CC=C(C(=C1)Br)N2C=CC=N2

Description

1-(2-Bromophenyl)pyrazole features a brominated phenyl ring directly fused to the pyrazole core, delivering enhanced electron-withdrawing character and improved metabolic stability. This structural motif enables efficient coupling in cross-coupling reactions and serves as a key scaffold in medicinal chemistry for targeted kinase inhibition and bioactive heterocycle synthesis under standard conditions.

Application

1-(2-Bromophenyl)pyrazole serves as a versatile building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. The bromine substituent enables palladium-catalyzed cross-coupling reactions, facilitating C–C bond formation under standard conditions. Its pyrazole core offers moderate stability and compatibility with common functional groups, enabling straightforward incorporation into complex molecular architectures via established synthetic protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.6348
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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