2,3,6-Trichloropyridin-4-amine

Name: 2,3,6-Trichloropyridin-4-amine
Brand: ChemScene
Availability: InStock
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CAS No. 874491-78-8
Cat. No. CS-0145990
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,3,6-Trichloropyridin-4-amine|CS-0145990

Structure of 874491-78-8

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General Information

CAS No. 874491-78-8
Cat. No. CS-0145990
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃Cl₃N₂
Molecular Weight 197.45
Synonym(s) 2,3,,6-TETRACHLOROPYRIDIN-4-AMINE
SMILES NC1=C(Cl)C(Cl)=NC(Cl)=C1

Description

2,3,6-Trichloropyridin-4-amine features a highly reactive pyridine core functionalized with three chlorine atoms at electron-deficient positions, enabling efficient coupling reactions. This bench-stable reagent integrates readily into synthetic pathways requiring selective substitution or as a building block for bioactive heterocycles.

Application

2,3,6-Trichloropyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient introduction of nitrogen-containing heterocycles via nucleophilic substitution. Its trichloro substitution pattern provides orthogonal reactivity for sequential functionalization, while the pyridinamine core offers robust bench stability and compatibility with standard coupling protocols. Facilitates rapid diversification in API scaffold development.

Synthesis

Route1
- In-stock
  
  2587-02-2
- ~%
- In-stock
  
  874491-78-8
References
- den Hertog et al. Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,690
Route2
- 17325-31-4
- ~%
- In-stock
  
  874491-78-8
References
- Stokes; v. Pechmann Chemische Berichte, 1886 , vol. 19, p. 2711
Route3
- In-stock
  
  16063-69-7
- ~%
- In-stock
  
  874491-78-8
References
- den Hertog et al. Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,690

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 38.91
LogP 2.624
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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2,3,6-Trichloropyridin-4-amine

CAS No. 874491-78-8

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