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Structure of 872122-54-8
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3-Ethynyl-5-fluoropyridine features a conjugated alkyne tethered to a fluorinated pyridine core, enabling efficient coupling in copper-catalyzed click reactions. The electron-deficient heterocycle enhances reactivity in transition metal-mediated transformations, while the terminal alkyne offers compatibility with diverse functionalization protocols. This compound serves as a key building block for bioactive scaffolds and advanced materials.
3-Ethynyl-5-fluoropyridine serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal reactivity profile. The ethynyl group facilitates efficient Sonogashira and Glaser-type couplings, while the fluorinated pyridine moiety provides enhanced metabolic stability and electronic modulation. This compound exhibits excellent bench stability, mild handling requirements, and compatibility with diverse functional groups, making it well-suited for constructing complex heterocyclic scaffolds in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: