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CS-W001157 4
Total: USD 88.00

Methyl 2-(2,6-difluorophenyl)acetate

  • CAS No. 872046-08-7

  • Cat. No. CS-0199483
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(2,6-difluorophenyl)acetate|CS-0199483

Structure of 872046-08-7

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General Information

  • CAS No. 872046-08-7
  • Cat. No. CS-0199483
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈F₂O₂
  • Molecular Weight 186.16
  • Synonym(s) methyl (2,6-difluorophenyl)acetate
  • SMILES COC(=O)CC1=C(C=CC=C1F)F

Description

Methyl 2-(2,6-difluorophenyl)acetate features a fluorinated aryl moiety that enhances metabolic stability and lipophilicity. This bench-stable ester integrates readily into synthetic routes for pharmaceutical intermediates, offering improved solubility and compatibility in polar aprotic solvents.

Application

Methyl 2-(2,6-difluorophenyl)acetate serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically relevant aryl-substituted acetic acid derivatives. Its bench-stable nature and compatibility with standard coupling reactions facilitate straightforward functionalization. The ortho-difluoro substitution pattern enhances metabolic stability and modulates electronic properties, making it particularly useful in the synthesis of pharmaceutical intermediates and heterocyclic scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.6803
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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