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CS-W001157 4
Total: USD 88.00

(3-Hydroxymethyl)phenylboronic acid

  • CAS No. 87199-15-3

  • Cat. No. CS-W007418
  • Purity≥98%
  • MDL No.MFCD01317846

*For research and further manufacturing use only, not for direct human use.

(3-Hydroxymethyl)phenylboronic acid|CS-W007418

Structure of 87199-15-3

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General Information

  • CAS No. 87199-15-3
  • Cat. No. CS-W007418
  • Purity ≥98%
  • MDL No. MFCD01317846
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉BO₃
  • Molecular Weight 151.96
  • Synonym(s) 3-Hydroxymethylbenzeneboronic acid
  • SMILES OCC1=CC(B(O)O)=CC=C1

Description

Bromoacetamido-PEG4-NHS ester is a PEG linker containing a bromide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Application

(3-Hydroxymethyl)phenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The ortho-hydroxymethyl group offers additional functionality for downstream derivatization, while the boronic acid moiety provides excellent bench stability and compatibility with diverse reaction conditions. Its defined regiochemistry and predictable reactivity make it ideal for the synthesis of complex pharmaceutical intermediates and functional materials.

Synthesis

  • Route1
    • null|null
      109-72-8
    • null|null
      121-43-7
    • In-stock
      (3-Bromophenyl)methanol|CS-W007761
      15852-73-0
    • ~98%
    • In-stock
      (3-Hydroxymethyl)phenylboronic acid|CS-W007418
      87199-15-3

    References

    • Texas Biotechnology Corporation Patent: US5444050 A1, 1995 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -1.1413
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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