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CS-W001157 4
Total: USD 88.00

4-Chloro-1H-pyrazolo[4,3-c]pyridine

  • CAS No. 871836-51-0

  • Cat. No. CS-W007974
  • Purity≥98%
  • MDL No.MFCD11870058

*For research and further manufacturing use only, not for direct human use.

4-Chloro-1H-pyrazolo[4,3-c]pyridine|CS-W007974

Structure of 871836-51-0

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General Information

  • CAS No. 871836-51-0
  • Cat. No. CS-W007974
  • Purity ≥98%
  • MDL No. MFCD11870058
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClN₃
  • Molecular Weight 153.57
  • Synonym(s) 1H-Pyrazolo[4,3-c]pyridine, 4-chloro-; 4-Chloro-1H-pyrazolo[4,3-c]pyridine
  • SMILES ClC1=NC=CC2=C1C=NN2

Description

4-Chloro-1H-pyrazolo[4,3-c]pyridine is a heterocyclic scaffold featuring a chlorinated pyrazolopyridine core, offering enhanced electron deficiency and structural rigidity. This motif integrates readily into medicinal chemistry campaigns, serving as a pivotal building block for kinase inhibitors and targeted therapeutics. Its bench-stable nature supports reliable handling in synthetic workflows.

Application

4-Chloro-1H-pyrazolo[4,3-c]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of bioactive scaffolds. Its chlorine substituent facilitates palladium-catalyzed cross-coupling reactions, while the fused pyrazolopyridine core provides structural rigidity and favorable pharmacophore geometry. The compound exhibits excellent bench stability and compatibility with common functional groups, making it well-suited for modular synthesis and process-scale applications.

Synthesis

  • Route1

    References

    • WO2010/106333 A1, ; Page/Page column 78-79 ; WO 2010/106333 A1
  • Route2

    References

    • WO2012/66061 A1, ; Page/Page column 77 ; WO 2012/066061 A1
  • Route3
    • null|null
      871836-50-9
    • ~%
    • In-stock
      4-Chloro-1H-pyrazolo[4,3-c]pyridine|CS-W007974
      871836-51-0

    References

    • WO2005/121094 A1, ; Page/Page column 52 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6113
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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