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CS-W001157 4
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1-(4-((Trifluoromethyl)thio)phenyl)ethanamine

  • CAS No. 871519-25-4

  • Cat. No. CS-0161929
  • Molecule weight221.24
  • Purity≥98%
  • MDL No.MFCD18703057

*For research and further manufacturing use only, not for direct human use.

1-(4-((Trifluoromethyl)thio)phenyl)ethanamine|CS-0161929

Structure of 871519-25-4

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General Information

  • CAS No. 871519-25-4
  • Cat. No. CS-0161929
  • Purity ≥98%
  • MDL No. MFCD18703057
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀F₃NS
  • Molecular Weight 221.24
  • Synonym(s) 1-(4-[(TRIFLUOROMETHYL)SULFANYL]PHENYL)ETHAN-1-AMINE
  • SMILES CC(N)C1=CC=C(SC(F)(F)F)C=C1

Description

1-(4-((Trifluoromethyl)thio)phenyl)ethanamine features a trifluoromethylthio group that imparts strong electron-withdrawing character and enhanced metabolic stability. The ethanamine side chain provides a primary amine handle for conjugation, enabling integration into bioactive molecules. This compound serves as a key building block in medicinal chemistry, particularly for designing kinase inhibitors and CNS-targeted therapeutics.

Application

1-(4-((Trifluoromethyl)thio)phenyl)ethanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethylthio group imparts enhanced metabolic stability and lipophilicity, while the primary amine facilitates standard coupling reactions. The compound exhibits bench stability and compatibility with common protecting group strategies, supporting efficient synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   3.3182
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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