Boc-Val-Cit-OH

Name: Boc-Val-Cit-OH
Brand: ChemScene
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CAS No. 870487-08-4
Cat. No. CS-0096160
Purity≥95%
MDL No.MFCD22381207

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 870487-08-4

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General Information

CAS No. 870487-08-4
Cat. No. CS-0096160
Purity ≥95%
MDL No. MFCD22381207
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₃₀N₄O₆
Molecular Weight 374.43
Synonym(s) None
SMILES O=C(O)[C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OC(C)(C)C)=O)=O

Description

Boc-Val-Cit-OH is a protected tripeptide linker featuring a valine-citrulline sequence with a C-terminal hydroxyl group. This stable, bench-ready intermediate integrates efficiently into antibody-drug conjugate (ADC) architectures, enabling site-specific payload attachment through cleavable linkers. The Boc group ensures compatibility with standard peptide synthesis protocols and provides enhanced stability during handling.

Application

Boc-Val-Cit-OH serves as a key building block in the synthesis of antibody-drug conjugates (ADCs), enabling site-specific drug attachment via its cleavable Val-Cit dipeptide linker. The Boc group provides stable protection of the N-terminus, while the C-terminal carboxylic acid facilitates efficient coupling reactions. This compound exhibits excellent bench stability, compatibility with standard peptide synthesis protocols, and reliable cleavage under physiological conditions, making it a practical choice for constructing bioconjugates in therapeutic development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 159.85
LogP 0.5536
H_Acceptors 5
H_Donors 5
Rotatable_Bonds 9

Other Classifications

Life Science Linker Peptide Linkers

Life Science Amino Acids and their Derivatives Valine and derivatives

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

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Boc-Val-Cit-OH

CAS No. 870487-08-4

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