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CS-W001157 4
Total: USD 88.00

(4-(Trifluoromethyl)pyridin-2-yl)boronic acid

  • CAS No. 870459-90-8

  • Cat. No. CS-W018367
  • Purity≥95%
  • MDL No.MFCD08063026

*For research and further manufacturing use only, not for direct human use.

(4-(Trifluoromethyl)pyridin-2-yl)boronic acid|CS-W018367

Structure of 870459-90-8

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General Information

  • CAS No. 870459-90-8
  • Cat. No. CS-W018367
  • Purity ≥95%
  • MDL No. MFCD08063026
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BF₃NO₂
  • Molecular Weight 190.92
  • Synonym(s) B-[4-(TRIFLUOROMETHYL)-2-PYRIDINYL] BORONIC ACID
  • SMILES OB(C1=NC=CC(C(F)(F)F)=C1)O

Description

This boronate moiety features a trifluoromethylpyridine scaffold, delivering enhanced stability and electron-deficient character. It enables efficient cross-coupling under standard conditions, pairing effectively with diverse partners in Suzuki-Miyaura reactions. The pendant pyridine ring facilitates directional coordination and improves solubility in polar media.

Application

(4-(Trifluoromethyl)pyridin-2-yl)boronic acid serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its trifluoromethylpyridine core provides enhanced metabolic stability and modulated electronic properties, making it valuable in medicinal chemistry. The boronic acid functionality offers reliable reactivity in Suzuki-Miyaura coupling under standard conditions, with good bench stability and straightforward purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.2198
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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