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CS-W001157 4
Total: USD 88.00

4-(Benzyloxy)benzenesulfonyl chloride

  • CAS No. 87001-32-9

  • Cat. No. CS-0156169
  • Molecule weight282.74
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Benzyloxy)benzenesulfonyl chloride|CS-0156169

Structure of 87001-32-9

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General Information

  • CAS No. 87001-32-9
  • Cat. No. CS-0156169
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₁ClO₃S
  • Molecular Weight 282.74
  • Synonym(s) 4-(Phenylmethoxy)benzenesulfonyl Chloride
  • SMILES C1=CC=C(C=C1)COC2=CC=C(C=C2)S(=O)(=O)Cl

Description

4-(Benzyloxy)benzenesulfonyl chloride is a bench-stable sulfonyl chloride reagent featuring a para-benzyloxy aryl group. This configuration enhances solubility in organic solvents while maintaining high reactivity toward nucleophiles. The compound facilitates efficient sulfonation of amines and alcohols under standard conditions, enabling streamlined access to functionalized sulfonamide and sulfate derivatives in synthetic workflows.

Application

4-(Benzyloxy)benzenesulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of sulfonamide groups under mild conditions. Its benzyloxy substituent enhances solubility and facilitates purification, while the reactive sulfonyl chloride moiety enables reliable coupling with amines, alcohols, and nucleophiles in standard organic synthesis. Ideal for building complex heterocycles and functionalized scaffolds in medicinal chemistry workflows.

Synthesis

  • Route1
    • null|null
      111712-04-0
    • ~97%
    • In-stock
      4-(Benzyloxy)benzenesulfonyl chloride|CS-0156169
      87001-32-9

    References

    • Liu, Juntao; Zhou, Yougui; Wu, Yinuo; Li, Xingshu; Chan, Albert S.C. Tetrahedron Asymmetry, 2008 , vol. 19, # 7 p. 832 - 837
  • Route2

    References

    • US5872138 A1, ; US 5872138 A
  • Route3
    • 4-(Benzyloxy)benzenesulfonic acid|CS-0668193
      5950-16-3
    • ~99%
    • In-stock
      4-(Benzyloxy)benzenesulfonyl chloride|CS-0156169
      87001-32-9

    References

    • Brinner, Kristin M; Mi Kim, Jin; Habashita, Hiromu; Gluzman, Ilya Y; Goldberg, Daniel E; Ellman, Jonathan A Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 11 p. 3649 - 3661

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   43.37
  • LogP   3.1931
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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