2-Amino-3-bromo-5-fluoropyridine

Name: 2-Amino-3-bromo-5-fluoropyridine
Brand: ChemScene
Availability: InStock
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CAS No. 869557-43-7
Cat. No. CS-W010739
Purity≥97%
MDL No.MFCD03092924

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Amino-3-bromo-5-fluoropyridine|CS-W010739

Structure of 869557-43-7

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General Information

CAS No. 869557-43-7
Cat. No. CS-W010739
Purity ≥97%
MDL No. MFCD03092924
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄BrFN₂
Molecular Weight 191.00
Synonym(s) 3-Bromo-5-fluoro-2-pyridinamine
SMILES BrC(C=C(F)C=N1)=C1N

Description

2-Amino-3-bromo-5-fluoropyridine features a pyridine core functionalized with amino, bromo, and fluoro groups at strategic positions. This electron-deficient heterocycle enables direct coupling in cross-coupling reactions and serves as a key scaffold for medicinal chemistry libraries. The combination of polar substituents enhances solubility and reactivity under standard conditions.

Application

2-Amino-3-bromo-5-fluoropyridine serves as a versatile building block for the synthesis of functionalized pyridine derivatives. Its orthogonal reactivity enables selective Suzuki-Miyaura and Ullmann couplings, while the amino group facilitates electrophilic substitution or derivatization. The molecule exhibits good bench stability and is compatible with standard purification methods, making it well-suited for medicinal chemistry campaigns and API intermediate development.

Synthesis

Route1
- In-stock
  
  21717-96-4
- ~31%
- In-stock
  
  869557-43-7
References
- AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge Patent: WO2011/143365 A1, 2011 ; Location in patent: Page/Page column 154 ; WO 2011/143365 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 3259
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 38.91
LogP 1.5654
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Amino-3-bromo-5-fluoropyridine

CAS No. 869557-43-7

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