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CS-W001157 4
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cis-3,4-Difluoropyrrolidine hydrochloride

  • CAS No. 869481-94-7

  • Cat. No. CS-0012663
  • Purity≥98%
  • MDL No.MFCD20230545

*For research and further manufacturing use only, not for direct human use.

cis-3,4-Difluoropyrrolidine hydrochloride|CS-0012663

Structure of 869481-94-7

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General Information

  • CAS No. 869481-94-7
  • Cat. No. CS-0012663
  • Purity ≥98%
  • MDL No. MFCD20230545
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈ClF₂N
  • Molecular Weight 143.56
  • Synonym(s) rel-(3S,4R)-3,4-Difluoropyrrolidine hydrochloride
  • SMILES F[C@H]1[C@@H](F)CNC1.Cl

Description

cis-3,4-Difluoropyrrolidine hydrochloride delivers a conformationally constrained, electron-deficient pyrrolidine scaffold ideal for probing stereoselective transformations. This bench-stable salt features enhanced solubility and predictable stereochemical control in synthetic applications, enabling efficient incorporation into bioactive molecules and catalytic systems.

Application

cis-3,4-Difluoropyrrolidine hydrochloride serves as a conformationally restricted, fluorinated building block for medicinal chemistry and catalytic synthesis. Its defined stereochemistry and enhanced metabolic stability enable direct incorporation into bioactive scaffolds. The hydrochloride salt ensures excellent solubility and bench stability, facilitating straightforward handling and purification in standard peptide and small-molecule workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   0.6876
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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