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CS-W001157 4
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4-Chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine

  • CAS No. 869335-73-9

  • Cat. No. CS-B0495
  • Purity≥97%
  • MDL No.MFCD09266226

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine|CS-B0495

Structure of 869335-73-9

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General Information

  • CAS No. 869335-73-9
  • Cat. No. CS-B0495
  • Purity ≥97%
  • MDL No. MFCD09266226
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClIN₂
  • Molecular Weight 278.48
  • Synonym(s) 4-Chlor-3-iod-1H-pyrrolo[2,3-b]pyridin
  • SMILES IC1=CNC2=NC=CC(Cl)=C21

Description

4-Chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine is a halogenated heterocyclic scaffold featuring orthogonal reactivity at chlorine and iodine positions. This electron-deficient pyrrolopyridine enables selective cross-coupling transformations under palladium catalysis, facilitating rapid access to complex molecular architectures in medicinal chemistry and materials science.

Application

4-Chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine serves as a versatile building block for constructing biologically relevant heterocyclic scaffolds. Its orthogonal halogen handles enable sequential cross-coupling reactions, facilitating efficient access to substituted pyrrolopyridines. The molecule exhibits excellent bench stability and compatibility with palladium-catalyzed transformations, making it well-suited for medicinal chemistry campaigns and API intermediate synthesis.

Synthesis

  • Route1

    References

    • US2006/128661 A1, ; Page/Page column 6 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.8209
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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