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CS-W001157 4
Total: USD 88.00

7-Bromo-3-methyl-1H-indole

  • CAS No. 86915-22-2

  • Cat. No. CS-0093897
  • Purity≥98%
  • MDL No.MFCD07799775

*For research and further manufacturing use only, not for direct human use.

7-Bromo-3-methyl-1H-indole|CS-0093897

Structure of 86915-22-2

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General Information

  • CAS No. 86915-22-2
  • Cat. No. CS-0093897
  • Purity ≥98%
  • MDL No. MFCD07799775
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈BrN
  • Molecular Weight 210.07
  • Synonym(s) 7-BroMo-3-Methylindole
  • SMILES BrC1=C(NC=C2C)C2=CC=C1

Description

7-Bromo-3-methyl-1H-indole features a brominated indole core with a methyl group at the 3-position, offering enhanced electron deficiency and improved stability under standard conditions. This scaffold serves as a key building block in medicinal chemistry, enabling direct incorporation into bioactive molecules via cross-coupling reactions.

Application

7-Bromo-3-methyl-1H-indole serves as a versatile building block for the synthesis of biologically active heterocycles, particularly in medicinal chemistry and agrochemical development. The bromine at C7 enables palladium-catalyzed cross-coupling reactions, while the methyl group at C3 provides a site for selective functionalization. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient access to complex indole scaffolds used in API discovery.

Synthesis

  • Route1
    • null|null
      242805-94-3
    • ~85%
    • In-stock
      7-Bromo-3-methyl-1H-indole|CS-0093897
      86915-22-2

    References

    • Fukuda, Tsutomu; Maeda, Ryoichi; Iwao, Masatomo Tetrahedron, 1999 , vol. 55, # 30 p. 9151 - 9162
  • Route2
    • null|null
      577-19-5
    • null|null
      1730-25-2
    • ~62%
    • In-stock
      7-Bromo-3-methyl-1H-indole|CS-0093897
      86915-22-2

    References

    • Dobbs Journal of Organic Chemistry, 2001 , vol. 66, # 2 p. 638 - 641
  • Route3
    • null|null
      577-19-5
    • null|null
      13154-14-8
    • ~61%
    • In-stock
      7-Bromo-3-methyl-1H-indole|CS-0093897
      86915-22-2

    References

    • Ghosh, Raju; Sarkar, Amitabha Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8283 - 8286

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   3.23882
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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