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CS-W001157 4
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2-Cyano-5-hydroxypyridine

  • CAS No. 86869-14-9

  • Cat. No. CS-W005464
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Cyano-5-hydroxypyridine|CS-W005464

Structure of 86869-14-9

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General Information

  • CAS No. 86869-14-9
  • Cat. No. CS-W005464
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄N₂O
  • Molecular Weight 120.11
  • Synonym(s) 5-hydroxypyridine-2-carbonitrile
  • SMILES OC1=CN=C(C#N)C=C1

Description

2-Cyano-5-hydroxypyridine features a strategically positioned hydroxyl group and nitrile moiety on a pyridine scaffold, enabling direct functionalization in synthetic transformations. The electron-deficient ring facilitates nucleophilic substitution, while the hydroxyl group offers a handle for derivatization under mild conditions. This compound serves as a key intermediate in heterocyclic synthesis.

Application

2-Cyano-5-hydroxypyridine serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted pyridines and heterocyclic scaffolds. The cyano group facilitates nucleophilic additions and subsequent transformations, while the hydroxyl moiety offers direct derivatization potential via etherification or esterification. Its stability under standard reaction conditions and compatibility with diverse functional groups make it a practical choice for medicinal chemistry lead optimization and process-scale synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.91
  • LogP   0.65888
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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