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CS-W001157 4
Total: USD 88.00

(6-(Trifluoromethyl)pyridin-3-yl)boronic acid

  • CAS No. 868662-36-6

  • Cat. No. CS-W004793
  • Purity≥98%
  • MDL No.MFCD07375381

*For research and further manufacturing use only, not for direct human use.

(6-(Trifluoromethyl)pyridin-3-yl)boronic acid|CS-W004793

Structure of 868662-36-6

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General Information

  • CAS No. 868662-36-6
  • Cat. No. CS-W004793
  • Purity ≥98%
  • MDL No. MFCD07375381
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BF₃NO₂
  • Molecular Weight None
  • Synonym(s) 6-(Trifluoromethyl)-3-pyridylboronic Acid (contains varying amounts of Anhydride)
  • SMILES FC(C1=NC=C(C=C1)B(O)O)(F)F

Description

This boronate moiety features a trifluoromethyl group at the 6-position of pyridin-3-yl, enhancing electron deficiency and metabolic stability. It enables efficient Suzuki-Miyaura coupling under standard conditions, delivering arylated products with high fidelity. The compound exhibits bench-stable handling and compatibility with diverse reaction matrices.

Application

(6-(Trifluoromethyl)pyridin-3-yl)boronic acid is a stable, bench-ready building block that facilitates Suzuki-Miyaura coupling reactions with high efficiency. Its trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable for constructing bioactive heterocycles in medicinal chemistry. The boronic acid functional group exhibits excellent compatibility with diverse electrophiles and tolerates common protecting groups, enabling straightforward access to complex scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.2198
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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