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Structure of 867367-02-0
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4-Fluoro-3,5-dimethylbenzonitrile features a trifluoromethyl-like electronic profile with enhanced steric shielding from ortho-methyl groups. This bench-stable aryl nitrile integrates readily into Suzuki-Miyaura couplings and serves as a key intermediate in bioactive molecule synthesis.
4-Fluoro-3,5-dimethylbenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering a trifunctional aromatic core with orthogonal reactivity. The nitrile group enables nucleophilic addition or conversion to amides and carboxylic acids, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The 3,5-dimethyl groups provide steric shielding and improve solubility, facilitating downstream functionalization. Its bench-stable nature and compatibility with standard coupling reactions make it a practical choice for constructing complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: