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CS-W001157 4
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6-Methoxy-5-methylpyridin-3-amine

  • CAS No. 867012-70-2

  • Cat. No. CS-W003211
  • Purity≥98%
  • MDL No.MFCD04972417

*For research and further manufacturing use only, not for direct human use.

6-Methoxy-5-methylpyridin-3-amine|CS-W003211

Structure of 867012-70-2

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General Information

  • CAS No. 867012-70-2
  • Cat. No. CS-W003211
  • Purity ≥98%
  • MDL No. MFCD04972417
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O
  • Molecular Weight 138.17
  • Synonym(s) 6-methoxy-5-methyl-pyridin-3-amine
  • SMILES COc1ncc(cc1C)N

Description

6-Methoxy-5-methylpyridin-3-amine features a pyridine core functionalized with methoxy and methyl groups at the 6- and 5-positions, respectively, and a primary amine at C3. This electron-rich scaffold integrates readily into medicinal chemistry libraries, offering enhanced solubility and metabolic stability for targeted kinase inhibitors and bioactive heterocycles.

Application

6-Methoxy-5-methylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds common in kinase inhibitors and CNS-targeted therapeutics. Its ortho-amino and methoxy groups offer complementary reactivity for Suzuki coupling, amide formation, and electrophilic substitution, while the methyl group enhances metabolic stability. The compound exhibits excellent bench stability and ease of purification, facilitating integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • EISAI CO., LTD. Patent: WO2005/103049 A1, 2005 ; Location in patent: Page/Page column 63-64 ;
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 9 p. 3056 - 3062

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.98082
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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