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CS-W001157 4
Total: USD 88.00

(4-Methoxy-3,5-dimethylpyridin-2-yl)methanol

  • CAS No. 86604-78-6

  • Cat. No. CS-W002741
  • Purity≥98%
  • MDL No.MFCD01076195

*For research and further manufacturing use only, not for direct human use.

(4-Methoxy-3,5-dimethylpyridin-2-yl)methanol|CS-W002741

Structure of 86604-78-6

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General Information

  • CAS No. 86604-78-6
  • Cat. No. CS-W002741
  • Purity ≥98%
  • MDL No. MFCD01076195
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃NO₂
  • Molecular Weight 167.21
  • Synonym(s) Pyrmethylalcohol
  • SMILES COc1c(C)cnc(c1C)CO

Description

This bench-stable methanol derivative features a 4-methoxy-3,5-dimethylpyridin-2-yl scaffold that combines electron-rich aromaticity with steric protection. The pendant hydroxyl group enables direct functionalization or derivatization in synthetic sequences. Its moisture-tolerant profile simplifies handling under standard conditions.

Application

(4-Methoxy-3,5-dimethylpyridin-2-yl)methanol serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyridine-based pharmacophores. Its methoxy and methyl substituents enhance metabolic stability and modulate electronic properties, while the benzylic alcohol functionality facilitates straightforward derivatization via oxidation, protection, or coupling reactions. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it well-suited for iterative library construction and scale-up applications.

Synthesis

  • Route1
    • (4-Methoxy-3,5-dimethylpyridin-2-yl)methyl acetate|CS-0162842
      91219-90-8
    • ~%
    • In-stock
      (4-Methoxy-3,5-dimethylpyridin-2-yl)methanol|CS-W002741
      86604-78-6

    References

    • Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1049 - 1057
  • Route2
    • (4-Chloro-3,5-dimethylpyridin-2-yl)methanol|CS-0159874
      150054-50-5
    • ~56%
    • In-stock
      (4-Methoxy-3,5-dimethylpyridin-2-yl)methanol|CS-W002741
      86604-78-6

    References

    • US6437139 B1, ;
  • Route3
    • null|null
      86604-80-0
    • ~%
    • In-stock
      (4-Methoxy-3,5-dimethylpyridin-2-yl)methanol|CS-W002741
      86604-78-6

    References

    • Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1777 - 1788

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   42.35
  • LogP   1.19934
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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