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CS-W001157 4
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(S)-5,6,7,8-Tetrahydroquinolin-8-amine dihydrochloride

  • CAS No. 865303-57-7

  • Cat. No. CS-M1732
  • Purity≥95%
  • MDL No.MFCD17926204

*For research and further manufacturing use only, not for direct human use.

(S)-5,6,7,8-Tetrahydroquinolin-8-amine dihydrochloride|CS-M1732

Structure of 865303-57-7

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General Information

  • CAS No. 865303-57-7
  • Cat. No. CS-M1732
  • Purity ≥95%
  • MDL No. MFCD17926204
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄Cl₂N₂
  • Molecular Weight None
  • Synonym(s) (s)-8-amino-5,6,7,8-tetrahydroquinoline 2hcl
  • SMILES N[C@@H]1C2=NC=CC=C2CCC1.Cl.Cl

Description

This bench-stable, moisture-tolerant chiral amine features a fully saturated quinoline core with a primary amine at the 8-position. The dihydrochloride salt form enhances solubility in aqueous and polar organic media, facilitating use in peptide coupling, asymmetric synthesis, and catalytic applications.

Application

(S)-5,6,7,8-Tetrahydroquinolin-8-amine dihydrochloride serves as a key chiral building block for the synthesis of bioactive heterocycles, enabling efficient access to quinoline-based scaffolds in medicinal chemistry. Its well-defined stereochemistry and solubility in common organic solvents facilitate straightforward functionalization and purification. The dihydrochloride salt enhances stability and handling, making it suitable for scale-up and integration into multi-step synthetic sequences involving amine coupling, cyclization, or metal-catalyzed transformations.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.2613
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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