(4-Bromopyridin-2-yl)methanamine

Name: (4-Bromopyridin-2-yl)methanamine
Brand: ChemScene
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CAS No. 865156-50-9
Cat. No. CS-W019223
Purity≥95%
MDL No.MFCD07374903

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(4-Bromopyridin-2-yl)methanamine|CS-W019223

Structure of 865156-50-9

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Description

(4-Bromopyridin-2-yl)methanamine features a pyridine ring bearing both bromo and amino-methyl substituents at meta positions, enabling direct functionalization in cross-coupling and nucleophilic substitution reactions. The electron-deficient pyridine ring enhances reactivity toward palladium-catalyzed transformations, while the primary amine group provides a handle for derivatization. This bifunctional scaffold supports efficient access to bioactive heterocycles and advanced intermediates in medicinal chemistry.

Application

(4-Bromopyridin-2-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds through palladium-catalyzed cross-coupling reactions. The bromine and primary amine functionalities offer orthogonal reactivity for sequential derivatization, while the compound exhibits good bench stability and ease of purification. Functions effectively in Suzuki, Sonogashira, and Buchwald-Hartwig coupling protocols, facilitating rapid access to diverse heterocyclic architectures relevant to drug discovery programs.

General Information

CAS No. 865156-50-9
Cat. No. CS-W019223
Purity ≥95%
MDL No. MFCD07374903
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇BrN₂
Molecular Weight 187.04
Synonym(s) 2-pyridinemethanamine, 4-bromo-
SMILES BrC1=CC(=NC=C1)CN

Computational Chemistry Data

TPSA 38.91
LogP 1.3028
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(4-Bromopyridin-2-yl)methanamine

CAS No. 865156-50-9

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