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CS-W001157 4
Total: USD 88.00

2-(Hydroxymethyl)pyridin-4-ol

  • CAS No. 860411-74-1

  • Cat. No. CS-0094528
  • Purity≥95%
  • MDL No.MFCD13175434

*For research and further manufacturing use only, not for direct human use.

2-(Hydroxymethyl)pyridin-4-ol|CS-0094528

Structure of 860411-74-1

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General Information

  • CAS No. 860411-74-1
  • Cat. No. CS-0094528
  • Purity ≥95%
  • MDL No. MFCD13175434
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂
  • Molecular Weight 125.13
  • Synonym(s) None
  • SMILES OCC1=NC=CC(O)=C1

Description

2-(Hydroxymethyl)pyridin-4-ol features a pyridine ring bearing both hydroxyl and hydroxymethyl groups in a para arrangement, enabling dual functionalization. This scaffold delivers enhanced solubility and stability under standard conditions, facilitating integration into complex synthetic sequences. The phenolic hydroxyl group supports metal coordination and hydrogen bonding, while the adjacent hydroxymethyl moiety serves as a reactive handle for derivatization.

Application

2-(Hydroxymethyl)pyridin-4-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through standard functional group interconversions. The ortho-hydroxy and hydroxymethyl groups provide complementary reactivity for derivatization, including oxidation to aldehyde, etherification, or coupling reactions. Its bench-stable nature and compatibility with common protecting group strategies facilitate reliable use in multi-step syntheses.

Synthesis

  • Route1
    • Metoprolol Impurity 48|CS-1005348
      933030-86-5
    • ~66%
    • In-stock
      2-(Hydroxymethyl)pyridin-4-ol|CS-0094528
      860411-74-1

    References

    • Lumetzberger, Astrid; Loewe, Werner; Weber, Manuela; Luger, Peter Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 1 p. 155 - 159

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P261-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   0.2795
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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