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CS-W001157 4
Total: USD 88.00

3-Fluoro-5-hydroxybenzoic acid

  • CAS No. 860296-12-4

  • Cat. No. CS-W005392
  • Purity≥98%
  • MDL No.MFCD11846515

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-5-hydroxybenzoic acid|CS-W005392

Structure of 860296-12-4

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General Information

  • CAS No. 860296-12-4
  • Cat. No. CS-W005392
  • Purity ≥98%
  • MDL No. MFCD11846515
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FO₃
  • Molecular Weight 156.11
  • Synonym(s) None
  • SMILES O=C(O)C1=CC(O)=CC(F)=C1

Description

3-Fluoro-5-hydroxybenzoic acid features a strategically positioned fluorine atom and hydroxyl group on the aromatic ring, enabling enhanced electronic modulation and hydrogen bonding capacity. This combination supports efficient conjugation in bioactive molecule synthesis and facilitates solubility in polar reaction media.

Application

3-Fluoro-5-hydroxybenzoic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates, offering orthogonal functionality for selective derivatization. The ortho-fluorine enables electrophilic substitution or palladium-catalyzed coupling, while the phenolic hydroxyl and carboxylic acid groups provide handles for esterification, amidation, or direct conjugation. Bench-stable and readily purified by recrystallization, it functions efficiently in standard synthetic workflows requiring precise regiocontrol and functional group compatibility.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   1.2295
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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