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Structure of 86-59-9
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Quinoline-8-carboxylic acid features a rigid heteroaromatic scaffold with a carboxylic acid group at the 8-position, enabling direct conjugation in bioactive molecule design. This configuration supports hydrogen bonding and dipole interactions, enhancing solubility and target engagement in medicinal chemistry applications. The electron-deficient quinoline ring facilitates π-stacking in protein-ligand interfaces.
Quinoline-8-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via amide bond formation or decarboxylative functionalization. Its carboxylic acid group provides high reactivity in standard coupling protocols, while the quinoline core offers favorable π-stacking and metabolic stability. Bench-stable and readily purified by recrystallization, it functions efficiently in both solution-phase synthesis and solid-phase workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: