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CS-W001157 4
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2-Methyl-2-morpholinopropan-1-ol

  • CAS No. 858197-58-7

  • Cat. No. CS-0315535
  • Purity≥98%
  • MDL No.MFCD11053919

*For research and further manufacturing use only, not for direct human use.

2-Methyl-2-morpholinopropan-1-ol|CS-0315535

Structure of 858197-58-7

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General Information

  • CAS No. 858197-58-7
  • Cat. No. CS-0315535
  • Purity ≥98%
  • MDL No. MFCD11053919
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₇NO₂
  • Molecular Weight 159.23
  • Synonym(s) 4-Morpholineethanol, β,β-dimethyl-
  • SMILES CC(C)(CO)N1CCOCC1

Description

2-Methyl-2-morpholinopropan-1-ol is a sterically hindered tertiary alcohol featuring a morpholine ring and a hydroxyl group at the 1-position. This structure imparts excellent solubility in polar aprotic solvents and enhances stability under basic conditions. The molecule serves as a robust scaffold for conjugate additions and acts as an effective nucleophilic catalyst in C–C bond-forming reactions.

Application

2-Methyl-2-morpholinopropan-1-ol serves as a stable, bench-ready building block for the synthesis of morpholine-containing pharmaceutical intermediates and bioactive heterocycles. Its tertiary alcohol functionality enables straightforward derivatization via Mitsunobu or esterification reactions, while the morpholinyl group provides favorable solubility and metabolic stability. The molecule exhibits excellent functional group tolerance and facilitates efficient purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • In-stock
      2-Amino-2-methyl-1-propanol|CS-W013743
      124-68-5
    • null|null
      111-44-4
    • ~%
    • In-stock
      2-Methyl-2-morpholinopropan-1-ol|CS-0315535
      858197-58-7

    References

    • Cheney; Bywater Journal of the American Chemical Society, 1942 , vol. 64, p. 970,972

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.7
  • LogP   0.0895
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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