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CS-W001157 4
Total: USD 88.00

3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

  • CAS No. 857530-80-4

  • Cat. No. CS-W004017
  • Purity≥97%
  • MDL No.MFCD05663852

*For research and further manufacturing use only, not for direct human use.

3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole|CS-W004017

Structure of 857530-80-4

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General Information

  • CAS No. 857530-80-4
  • Cat. No. CS-W004017
  • Purity ≥97%
  • MDL No. MFCD05663852
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉BN₂O₂
  • Molecular Weight 222.09
  • Synonym(s) 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,4-dimethyl-1H-pyrazole
  • SMILES Cc1[nH]nc(c1B1OC(C(O1)(C)C)(C)C)C

Application

3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole serves as a robust boronate building block for Suzuki-Miyaura cross-coupling reactions. Its pyrazole core offers enhanced stability and mild reactivity, enabling efficient C–C bond formation under standard conditions. The tetramethyl-substituted dioxaborolane group ensures excellent shelf life, low hydrolytic sensitivity, and compatibility with diverse functional groups, facilitating straightforward purification and integration into complex molecular architectures.

Synthesis

  • Route1
    • null|null
      67-51-6
    • In-stock
      Bis(pinacolato)diborane|CS-D1216
      73183-34-3
    • ~59%
    • In-stock
      3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole|CS-W004017
      857530-80-4

    References

    • Larsen, Matthew A.; Hartwig, John F. Journal of the American Chemical Society, 2014 , vol. 136, # 11 p. 4287 - 4299

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   47.14
  • LogP   1.32574
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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