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CS-W001157 4
Total: USD 88.00

Temozolomide

  • CAS No. 85622-93-1

  • Cat. No. CS-0943
  • Purity≥98%
  • MDL No.MFCD00866492

*For research and further manufacturing use only, not for direct human use.

Temozolomide|CS-0943

Structure of 85622-93-1

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General Information

  • CAS No. 85622-93-1
  • Cat. No. CS-0943
  • Purity ≥98%
  • MDL No. MFCD00866492
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₆O₂
  • Molecular Weight 194.15
  • Synonym(s) NSC 362856; CCRG 81045; TMZ
  • SMILES O=C(C1=C(N2C=N1)N=NN(C)C2=O)N

Description

Flake graphite is a naturally occurring form of graphite that is typically found as discrete flakes ranging in size from 50-800 m in diameter and 1-150 m thick. This form of graphite has a high degree of crystallinity, which equates to near theoretical true density, high thermal and electric conductivity and low springback (excellent molding characteristics).Graphene precursorInorganic source of carbonFillerThermal additiveRe-carburizerCasting powdersDrilling fluidsPlastic additiveRubber additiveTint/pigmentLubricantChemically resistant additiveEMF absorberMilling and sievingGeneral inert filler-additive

Application

Temozolomide serves as a well-established prodrug in oncology, undergoing spontaneous hydrolysis at physiological pH to generate the active metabolite MTIC, which methylates DNA at the O6-guanine position. Its stability under ambient conditions enables reliable handling and storage, while its predictable activation profile supports consistent cytotoxicity in glioblastoma and other malignancies. Functions as a key alkylating agent in standard regimens for brain tumors.

Synthesis

  • Route1
    • null|null
      624-83-9
    • 4-Diazo-4H-imidazole-5-carboxamide|CS-0654577
      7008-85-7
    • ~96%
    • In-stock
      Temozolomide|CS-0943
      85622-93-1

    References

    • Journal of Medicinal Chemistry, , vol. 27, # 2 p. 196 - 201
  • Route2
    • 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide|CS-0016860
      188612-53-5
    • ~62%
    • In-stock
      Temozolomide|CS-0943
      85622-93-1

    References

    • WO2008/38031 A1, ; Page/Page column 9 ;
  • Route3
    • null|null
      1161825-88-2
    • null|null
      74-88-4
    • ~22%
    • In-stock
      Temozolomide|CS-0943
      85622-93-1

    References

    • WO2009/77741 A2, ; Page/Page column 92-93 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335-H340-H350-H360
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   108.17
  • LogP   -2.0781
  • H_Acceptors   7
  • H_Donors   1
  • Rotatable_Bonds   1

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