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CS-W001157 4
Total: USD 88.00

1-(2-Chloropyridin-4-yl)piperazine

  • CAS No. 854159-45-8

  • Cat. No. CS-B1032
  • Purity≥97%
  • MDL No.MFCD06738480

*For research and further manufacturing use only, not for direct human use.

1-(2-Chloropyridin-4-yl)piperazine|CS-B1032

Structure of 854159-45-8

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General Information

  • CAS No. 854159-45-8
  • Cat. No. CS-B1032
  • Purity ≥97%
  • MDL No. MFCD06738480
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂ClN₃
  • Molecular Weight 197.66
  • Synonym(s) 1-(2-CHLORO-PYRIDIN-4-YL)-PIPERAZINE
  • SMILES ClC1=NC=CC(N2CCNCC2)=C1

Description

1-(2-Chloropyridin-4-yl)piperazine features a chlorinated pyridine moiety linked to a piperazine ring, delivering enhanced solubility and metabolic stability. This scaffold integrates readily into kinase inhibitors and CNS-targeted compounds, offering strong hydrogen-bonding capacity and favorable pharmacokinetic traits.

Application

1-(2-Chloropyridin-4-yl)piperazine serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. The chloropyridine moiety facilitates palladium-catalyzed cross-coupling reactions, while the piperazine nitrogen supports derivatization and solubility enhancement. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for kinase inhibitors and CNS-targeted compounds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.16
  • LogP   1.1446
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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