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CS-W001157 4
Total: USD 88.00

4-(4-Boc-Piperazino)benzylamine

  • CAS No. 852180-47-3

  • Cat. No. CS-0213425
  • Purity≥97%
  • MDL No.MFCD03791213

*For research and further manufacturing use only, not for direct human use.

4-(4-Boc-Piperazino)benzylamine|CS-0213425

Structure of 852180-47-3

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General Information

  • CAS No. 852180-47-3
  • Cat. No. CS-0213425
  • Purity ≥97%
  • MDL No. MFCD03791213
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₅N₃O₂
  • Molecular Weight 291.40
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCN(C2=CC=C(C=C2)CN)CC1

Description

4-(4-Boc-Piperazino)benzylamine features a Boc-protected piperazine moiety linked to a benzylamine scaffold, enabling seamless deprotection and integration into diverse synthetic sequences. This bench-stable, moisture-tolerant building block facilitates rapid access to bioactive amines and functionalized scaffolds in medicinal chemistry and chemical biology applications.

Application

4-(4-Boc-Piperazino)benzylamine serves as a versatile bifunctional building block for medicinal chemistry and process development. The Boc-protected piperazine moiety enables selective deprotection under mild acidic conditions, while the primary benzylamine functionality facilitates amide coupling, reductive amination, or conjugation reactions. Its stability under standard handling conditions and compatibility with diverse functional groups make it ideal for constructing complex scaffolds in API synthesis.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 10 p. 2584 - 2589
  • Route2
    • null|null
      1194-02-1
    • ~%
    • In-stock
      4-(4-Boc-Piperazino)benzylamine|CS-0213425
      852180-47-3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 10 p. 2584 - 2589
  • Route3
    • N-Boc-piperazine Olaparib Impurity|CS-0214004
      57260-71-6
    • ~%
    • In-stock
      4-(4-Boc-Piperazino)benzylamine|CS-0213425
      852180-47-3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 10 p. 2584 - 2589

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.8
  • LogP   2.2024
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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