2-Chloro-6-methyl-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine

Name: 2-Chloro-6-methyl-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine
Brand: ChemScene
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CAS No. 851435-28-4
Cat. No. CS-0095076
Molecule weight223.66
Purity≥97%
MDL No.MFCD26393306

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-Chloro-6-methyl-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine|CS-0095076

Structure of 851435-28-4

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General Information

CAS No. 851435-28-4
Cat. No. CS-0095076
Purity ≥97%
MDL No. MFCD26393306
Storage 4°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₀ClN₅
Molecular Weight 223.66
Synonym(s) (2-Chloro-6-methyl-pyrimidin-4-yl)-(5-methyl-3H-pyrazol-3-yl)-amine
SMILES CC1=CC(NC2=NC(Cl)=NC(C)=C2)=NN1

Description

2-Chloro-6-methyl-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine features a pyrimidine core functionalized with a chloro group at C2, a methyl substituent at C6, and a 5-methyl-1H-pyrazol-3-yl amine at N4. This electron-deficient heterocycle integrates readily into kinase inhibitor scaffolds, offering enhanced metabolic stability and targeted binding affinity in medicinal chemistry applications.

Application

2-Chloro-6-methyl-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its chloro group facilitates nucleophilic substitution reactions, while the pyrazole and methyl functionalities offer orthogonal reactivity and enhanced metabolic stability. The compound exhibits good bench stability and is compatible with standard coupling protocols, simplifying purification and scale-up in API development workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 66.49
LogP 2.21354
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-6-methyl-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine

CAS No. 851435-28-4

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