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CS-W001157 4
Total: USD 88.00

4-Chloro-2-ethoxyphenylboronic acid

  • CAS No. 850568-80-8

  • Cat. No. CS-W015597
  • Purity≥98%
  • MDL No.MFCD03094940

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-ethoxyphenylboronic acid|CS-W015597

Structure of 850568-80-8

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General Information

  • CAS No. 850568-80-8
  • Cat. No. CS-W015597
  • Purity ≥98%
  • MDL No. MFCD03094940
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀BClO₃
  • Molecular Weight 200.43
  • Synonym(s) 4-Chloro-2-ethoxybenzeneboronic Acid (contains varying amounts of Anhydride)
  • SMILES CCOC1=C(C=CC(Cl)=C1)B(O)O

Description

4-Chloro-2-ethoxyphenylboronic acid delivers a reactive boronate handle flanked by electron-withdrawing chlorine and ethoxy substituents, enabling efficient cross-coupling under standard conditions. This bench-stable reagent integrates seamlessly into Suzuki-Miyaura protocols for constructing complex aryl architectures with enhanced regiocontrol.

Application

4-Chloro-2-ethoxyphenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds. The chloro and ethoxy substituents provide orthogonal reactivity and enhanced solubility, while the boronic acid moiety offers excellent bench stability and compatibility with diverse reaction conditions. Its defined substitution pattern facilitates predictable coupling outcomes and simplifies purification, making it ideal for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P280-P304+P340-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.4185
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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