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tert-Butyl (2-(aminomethyl)phenyl)carbamate

  • CAS No. 849020-94-6

  • Cat. No. CS-W005861
  • Purity≥98%
  • MDL No.MFCD04037902

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (2-(aminomethyl)phenyl)carbamate|CS-W005861

Structure of 849020-94-6

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General Information

  • CAS No. 849020-94-6
  • Cat. No. CS-W005861
  • Purity ≥98%
  • MDL No. MFCD04037902
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₈N₂O₂
  • Molecular Weight 222.28
  • Synonym(s) tert-Butyl2-(aminomethyl)phenylcarbamate
  • SMILES O=C(OC(C)(C)C)NC1=CC=CC=C1CN

Application

tert-Butyl (2-(aminomethyl)phenyl)carbamate serves as a versatile ortho-aminomethyl phenyl building block, enabling direct access to biologically relevant indole and benzimidazole scaffolds. Its robust tert-butyl carbamate protecting group offers excellent bench stability and facile removal under mild acidic conditions, while the pendant primary amine supports diverse functionalization via standard coupling and reductive amination protocols.

Synthesis

  • Route1
    • null|null
      1244783-42-3
    • ~10%
    • In-stock
      tert-Butyl (2-(aminomethyl)phenyl)carbamate|CS-W005861
      849020-94-6

    References

    • Tetrahedron Letters, , vol. 51, # 36 p. 4689 - 4692
  • Route2
    • null|null
      1222185-03-6
    • ~%
    • In-stock
      tert-Butyl (2-(aminomethyl)phenyl)carbamate|CS-W005861
      849020-94-6

    References

    • WO2010/43866 A2, ; Page/Page column 84 ; WO 2010/043866 A2
  • Route3

    References

    • US6927294 B1, ; Page/Page column 18 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H302-H317
Precautionary Statements : P210-P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P370+P378-P403-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   2.4923
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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