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CS-W001157 4
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N-Methylcyclobutanamine hydrochloride

  • CAS No. 848497-98-3

  • Cat. No. CS-0054580
  • Purity≥97%
  • MDL No.MFCD11506003

*For research and further manufacturing use only, not for direct human use.

N-Methylcyclobutanamine hydrochloride|CS-0054580

Structure of 848497-98-3

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General Information

  • CAS No. 848497-98-3
  • Cat. No. CS-0054580
  • Purity ≥97%
  • MDL No. MFCD11506003
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClN
  • Molecular Weight 121.61
  • Synonym(s) CYCLOBUTYL-METHYL-AMINE HYDROCHLORIDE
  • SMILES CNC1CCC1.[H]Cl

Description

N-Methylcyclobutanamine hydrochloride is a bench-stable, moisture-tolerant amine derivative featuring a constrained cyclobutane ring that enhances rigidity and metabolic stability. This nitrogen-containing scaffold integrates readily into bioactive molecule design, offering improved solubility and predictable protonation behavior in synthetic and medicinal chemistry applications.

Application

N-Methylcyclobutanamine hydrochloride serves as a versatile nitrogen-containing building block in medicinal chemistry, enabling efficient access to cyclic amine scaffolds. Its stable hydrochloride salt form facilitates handling and purification, while the N-methyl group enhances metabolic stability and lipophilicity. It functions effectively in nucleophilic substitution reactions and serves as a key intermediate in the synthesis of bioactive molecules and heterocyclic compounds.

Synthesis

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    • In-stock
      N-Methylcyclobutanamine hydrochloride|CS-0054580
      848497-98-3

    References

    • Giardina; Clarke; Dondio; Petrone; Sbacchi; Vecchietti Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3482 - 3491

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.1801
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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