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CS-W001157 4
Total: USD 88.00

N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide

  • CAS No. 848133-75-5

  • Cat. No. CS-0001164
  • Purity≥95%
  • MDL No.MFCD09029047

*For research and further manufacturing use only, not for direct human use.

N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide|CS-0001164

Structure of 848133-75-5

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General Information

  • CAS No. 848133-75-5
  • Cat. No. CS-0001164
  • Purity ≥95%
  • MDL No. MFCD09029047
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₃N₃O₃
  • Molecular Weight 271.27
  • Synonym(s) N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide
  • SMILES N#CC1=C(O)C2=CC(NC(C)=O)=C(OCC)C=C2N=C1

Synthesis

  • Route1
    • null|null
      1222172-54-4
    • ~94%
    • N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide|CS-0001164
      848133-75-5

    References

    • Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Topharman Shangai Co., Ltd. Patent: US2011/263860 A1, 2011 ; Location in patent: Page/Page column 9-10 ;
  • Route2
    • N-(4-(2,2-dicyanovinylamino)-2-ethoxyphenyl)acetamide|CS-0005865
      848133-74-4
    • ~42%
    • N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide|CS-0001164
      848133-75-5

    References

    • Wyeth Patent: US2005/65181 A1, 2005 ; Location in patent: Page/Page column 3-4 ;
  • Route3
    • Neratinib Impurity 70|CS-1000743
      1222172-50-0
    • ~93%
    • N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide|CS-0001164
      848133-75-5

    References

    • Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Topharman Shangai Co., Ltd. Patent: US2011/263860 A1, 2011 ; Location in patent: Page/Page column 8 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   95.24
  • LogP   2.16918
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   3

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