Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-[4-(Hydroxymethyl)piperidin-1-yl]ethan-1-one

  • CAS No. 846057-27-0

  • Cat. No. CS-0052674
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-[4-(Hydroxymethyl)piperidin-1-yl]ethan-1-one|CS-0052674

Structure of 846057-27-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 846057-27-0
  • Cat. No. CS-0052674
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅NO₂
  • Molecular Weight 157.21
  • Synonym(s) Ethanone, 1-[4-(hydroxymethyl)-1-piperidinyl]-
  • SMILES CC(=O)N1CCC(CO)CC1

Description

This piperidine-based ketone features a hydroxymethyl group enabling direct functionalization or derivatization. The carbonyl moiety supports nucleophilic addition, while the pendant hydroxyl offers hydrogen-bonding capacity. Bench-stable and compatible with standard synthetic protocols, it serves as a versatile scaffold for medicinal chemistry campaigns requiring polar, nitrogen-rich motifs.

Application

1-[4-(Hydroxymethyl)piperidin-1-yl]ethan-1-one serves as a versatile building block in medicinal chemistry, enabling the construction of piperidine-based scaffolds through subsequent functionalization. The pendant hydroxymethyl group facilitates derivatization via oxidation, protection, or coupling reactions, while the acetyl functionality provides a handle for selective transformations. Bench-stable and compatible with standard synthetic workflows, it supports efficient access to bioactive molecules in drug discovery programs.

Synthesis

  • Route1
    • In-stock
      4-Piperidinemethanol|CS-W002476
      6457-49-4
    • null|null
      64-19-7
    • ~39%
    • In-stock
      1-[4-(Hydroxymethyl)piperidin-1-yl]ethan-1-one|CS-0052674
      846057-27-0

    References

    • DONG-A-PHARM. CO., LTD. Patent: US2010/105727 A1, 2010 ; Location in patent: Page/Page column 12-13 ; US 20100105727 A1
  • Route2
    • null|null
      2494-10-2
    • ~%
    • In-stock
      1-[4-(Hydroxymethyl)piperidin-1-yl]ethan-1-one|CS-0052674
      846057-27-0

    References

    • Rhone-Poulenc Sante Patent: US4898871 A1, 1990 ;
  • Route3
    • In-stock
      4-Piperidinemethanol|CS-W002476
      6457-49-4
    • null|null
      108-24-7
    • ~96%
    • In-stock
      1-[4-(Hydroxymethyl)piperidin-1-yl]ethan-1-one|CS-0052674
      846057-27-0

    References

    • Iwasaki, Takanori; Maegawa, Yusuke; Hayashi, Yukiko; Ohshima, Takashi; Mashima, Kazushi Synlett, 2009 , # 10 p. 1659 - 1663

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P261-P302+P352

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   40.54
  • LogP   0.2372
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 846057-27-0 sigma846057-27-0 manufacturer846057-27-0 price846057-27-0 structure846057-27-0 SDSbuy 846057-27-0846057-27-0 supplier846057-27-0 uses846057-27-0 molecular weightprice of 846057-27-0846057-27-0 chemical name formula of 846057-27-0
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label