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CS-W001157 4
Total: USD 88.00

7-Methoxyindoline-2,3-dione

  • CAS No. 84575-27-9

  • Cat. No. CS-W005169
  • Purity≥95%
  • MDL No.MFCD00666831

*For research and further manufacturing use only, not for direct human use.

7-Methoxyindoline-2,3-dione|CS-W005169

Structure of 84575-27-9

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General Information

  • CAS No. 84575-27-9
  • Cat. No. CS-W005169
  • Purity ≥95%
  • MDL No. MFCD00666831
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇NO₃
  • Molecular Weight None
  • Synonym(s) 7-Methoxy-1H-indole-2,3-dione
  • SMILES O=C1NC2=C(C=CC=C2OC)C1=O

Description

7-Methoxyindoline-2,3-dione features a methoxy-substituted indoline core with two adjacent carbonyl groups, delivering enhanced solubility and stability compared to unsubstituted analogs. This electron-deficient scaffold serves as a robust building block in heterocyclic synthesis, particularly for constructing complex alkaloid frameworks and bioactive molecules under mild reaction conditions.

Application

7-Methoxyindoline-2,3-dione serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted indole and isoindolinone scaffolds. Its methoxy group enhances solubility and modulates reactivity, while the quinone-like core facilitates Diels-Alder cycloadditions and nucleophilic transformations. The compound exhibits bench stability and compatibility with common functional groups, making it suitable for iterative synthesis workflows in medicinal chemistry and materials science.

Synthesis

  • Route1
    • null|null
      90-04-0
    • ~%
    • In-stock
      7-Methoxyindoline-2,3-dione|CS-W005169
      84575-27-9

    References

    • Journal of Medicinal Chemistry, , vol. 50, # 1 p. 21 - 39
  • Route2
    • null|null
      401585-33-9
    • ~%
    • In-stock
      7-Methoxyindoline-2,3-dione|CS-W005169
      84575-27-9

    References

    • DE215785 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 10, p. 523
  • Route3

    References

    • DE215785 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 10, p. 523

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P301+P310-P305+P351+P338-P330-P337+P313-P501

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Computational Chemistry Data

  • TPSA   55.4
  • LogP   0.83
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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