Lot numbers can be found on the outside label of a product:
tert-Butyl 2,4-dioxopiperidine-1-carboxylate
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CAS No. 845267-78-9
- Cat. No. CS-W004740
- Purity≥95%
- MDL No.MFCD10566071
*For research and further manufacturing use only, not for direct human use.
Structure of 845267-78-9
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General Information
- CAS No. 845267-78-9
- Cat. No. CS-W004740
- Purity ≥95%
- MDL No. MFCD10566071
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₅NO₄
- Molecular Weight 213.23
- Synonym(s) 1-Boc-Piperidine-2,4-dione
- SMILES C(=O)(OC(C)(C)C)N1CCC(CC1=O)=O
Description
tert-Butyl 2,4-dioxopiperidine-1-carboxylate features a strained piperidinone core with dual carbonyl groups at C2 and C4, enabling selective reactivity in synthetic transformations. The tert-butyl ester moiety provides stability under basic conditions while facilitating mild deprotection. This compound serves as a key intermediate in the construction of complex nitrogen-containing scaffolds, particularly in medicinal chemistry applications involving heterocyclic ring systems.
Application
tert-Butyl 2,4-dioxopiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. Its 2,4-dioxo functionality facilitates nucleophilic addition and reductive amination, while the tert-butoxycarbonyl group provides stable protection under standard reaction conditions. The compound exhibits excellent bench stability and compatibility with diverse transformations, including hydrogenation and coupling reactions, making it ideal for iterative synthesis of complex heterocycles and API intermediates.
Synthesis
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Route1
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865364-92-7 - ~%
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In-stock
845267-78-9
References
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US2010/4239 A1, ; Page/Page column 99 ;
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Route2
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In-stock
3303-84-2 - ~%
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845267-78-9
References
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Tetrahedron Letters, , vol. 52, # 39 p. 5036 - 5038
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Route3
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In-stock
24424-99-5 - ~%
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845267-78-9
References
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WO2012/35078 A1, ; WO 2012/035078 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 63.68
- LogP 1.113
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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