Lot numbers can be found on the outside label of a product:
Benzyl 3-fluoro-4-oxopiperidine-1-carboxylate
-
CAS No. 845256-59-9
- Cat. No. CS-W001653
- Purity≥95%
- MDL No.MFCD11976639
*For research and further manufacturing use only, not for direct human use.
Structure of 845256-59-9
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 845256-59-9
- Cat. No. CS-W001653
- Purity ≥95%
- MDL No. MFCD11976639
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₁₄FNO₃
- Molecular Weight 251.25
- Synonym(s) Benzyl-3-fluoro-4-oxopioeridine-1-carboxylate
- SMILES O=C1CCN(CC1F)C(=O)OCc1ccccc1
Description
Benzyl 3-fluoro-4-oxopiperidine-1-carboxylate is a fluorinated piperidine scaffold featuring a labile carbamate protecting group. This compound integrates a strategically positioned fluorine atom and a ketone functionality, enabling direct functionalization at the C3 position. The benzyl ester moiety offers convenient deprotection under standard hydrogenolysis conditions.
Application
Benzyl 3-fluoro-4-oxopiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated piperidine scaffolds. The molecule combines a stable benzyl carbamate protecting group with a C3-fluorinated, C4-oxo piperidine core, facilitating downstream transformations such as reductive amination, nucleophilic addition, and cyclization reactions. Its bench-stable nature and compatibility with diverse reaction conditions support scalable synthesis of bioactive heterocycles.
Synthesis
-
Route1
-
355006-62-1 - ~90%
-
In-stock
845256-59-9
References
-
Liu, Jack; Chan, Johann; Bryant, Craig M.; Duspara, Petar A.; Lee, Ernest E.; Powell, David; Yang, Hua; Liu, Ziping; Walpole, Chris; Roberts, Edward; Batey, Robert A. Tetrahedron Letters, 2012 , vol. 53, # 24 p. 2971 - 2975
-
-
Route2
-
1147998-34-2 - ~81%
-
In-stock
845256-59-9
References
-
GLAXOSMITHKLINE LLC; ADAMS, Nicholas, David; CHAUDHARI, Amita, M.; KIESOW, Terence, John; McSHERRY, Allison, K.; MOORE, Michael, Lee; PARRISH, Cynthia, Ann; REIF, Alexander, Joseph; RIDGERS, Lance, Howard Patent: WO2014/8223 A2, 2014 ; Location in patent: Page/Page column 110 ;
-
-
Route3
-
913574-94-4 - ~%
-
In-stock
845256-59-9
References
-
WO2006/113471 A2, ; Page/Page column 27; 56 ; WO 2006/113471 A2
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 46.61
- LogP 1.9361
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 2
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 845256-59-9 sigma845256-59-9 manufacturer845256-59-9 price845256-59-9 structure845256-59-9 SDSbuy 845256-59-9845256-59-9 supplier845256-59-9 uses845256-59-9 molecular weightprice of 845256-59-9845256-59-9 chemical name formula of 845256-59-9