Lot numbers can be found on the outside label of a product:
1-Boc-(S)-4-Methylenepyrrolidine-2-carboxylic acid
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CAS No. 84348-38-9
- Cat. No. CS-0009247
- Purity≥97%
- MDL No.MFCD01861787
*For research and further manufacturing use only, not for direct human use.
Structure of 84348-38-9
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General Information
- CAS No. 84348-38-9
- Cat. No. CS-0009247
- Purity ≥97%
- MDL No. MFCD01861787
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₇NO₄
- Molecular Weight 227.26
- Synonym(s) N-Boc-4-methylene-L-proline
- SMILES O=C([C@H](C1)N(C(OC(C)(C)C)=O)CC1=C)O
Description
1-Boc-(S)-4-Methylenepyrrolidine-2-carboxylic acid is a stereochemically defined, bench-stable building block featuring a pyrrolidine core with a strategically positioned methylene group and a Boc-protected carboxylic acid. This configuration enables direct incorporation into complex heterocyclic scaffolds and facilitates efficient diversification in medicinal chemistry campaigns.
Application
1-Boc-(S)-4-Methylenepyrrolidine-2-carboxylic acid serves as a versatile chiral building block for the synthesis of pyrrolidine-containing scaffolds. Its protected amine and exocyclic methylene group enable efficient functionalization, facilitating C–C bond formation and heterocycle construction under standard coupling conditions. The Boc group provides bench stability and simplifies purification, while the (S)-configuration ensures stereochemical fidelity in downstream transformations relevant to medicinal chemistry and process development.
Synthesis
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Route1
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1779-49-3 -
In-stock
84348-37-8 - ~64%
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In-stock
84348-38-9
References
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ENANTA PHARMACEUTICALS, INC.; QIU, Yao-Ling; PENG, Xiaowen; KIM, In, Jong; CAO, Hui; TANG, Datong; OR, Yat, Sun; WANG, Guoqiang; XU, Guoyou Patent: WO2012/158861 A2, 2012 ; Location in patent: Page/Page column 19-20 ;
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Route2
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In-stock
84348-39-0 - ~%
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In-stock
84348-38-9
References
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Manfre; Kern; Biellmann Journal of Organic Chemistry, 1992 , vol. 57, # 7 p. 2060 - 2065
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Route3
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144422-81-1
- ~%
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In-stock
84348-38-9
References
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Tetrahedron, , vol. 48, # 31 p. 6529 - 6536
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352
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Quality Control
Computational Chemistry Data
- TPSA 66.84
- LogP 1.6366
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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