8-Chloropyrido[3,4-d]pyrimidin-4(3H)-one

Name: 8-Chloropyrido[3,4-d]pyrimidin-4(3H)-one
Brand: ChemScene
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CAS No. 84341-13-9
Cat. No. CS-0136600
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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8-Chloropyrido[3,4-d]pyrimidin-4(3H)-one|CS-0136600

Structure of 84341-13-9

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General Information

CAS No. 84341-13-9
Cat. No. CS-0136600
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄ClN₃O
Molecular Weight 181.58
Synonym(s) 8-Chloropyrido[3,4-d]pyrimidin-4-ol
SMILES O=C1C2=C(C(Cl)=NC=C2)N=CN1

Description

8-Chloropyrido[3,4-d]pyrimidin-4(3H)-one is a heterocyclic scaffold featuring a chlorinated pyridopyrimidinone core, offering enhanced electron-deficient character for targeted conjugation. This bench-stable compound integrates readily into medicinal chemistry campaigns, serving as a key building block for kinase inhibitors and nucleoside analogs through its reactive C8 position.

Application

8-Chloropyrido[3,4-d]pyrimidin-4(3H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to purine and pyrimidine analogs. Its well-defined reactivity facilitates nucleophilic substitution at the C8 position and supports functionalization under mild conditions. The compound exhibits excellent bench stability and compatibility with common protecting group strategies, making it suitable for multi-step synthesis workflows in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

TPSA 58.64
LogP 0.9715
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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8-Chloropyrido[3,4-d]pyrimidin-4(3H)-one

CAS No. 84341-13-9

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